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How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections

How do you hold on to hope while still being realistic about the work that needs to be done? Immunology researcher David Fajgenbaum and public health expert Celina de Sola discuss how they scaled personal missions into organizations making long-term impact on communities near and far. They explore how to stay motivated, discover your leadership…

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How do you hold on to hope while still being realistic about the work that needs to be done? Immunology researcher David Fajgenbaum and public health expert Celina de Sola discuss how they scaled personal missions into organizations making long-term impact on communities near and far. They explore how to stay motivated, discover your leadership style and uncover overlooked solutions hiding in plain sight. (This conversation is part of “TED Intersections,” a series featuring thought-provoking conversations between experts navigating the ideas shaping our world.)

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The TED Talks channel features talks, performances and original series from the world’s leading thinkers and doers. Subscribe to our channel for videos on Technology, Entertainment and Design — plus science, business, global issues, the arts and more. Visit to get our entire library of TED Talks, transcripts, translations, personalized talk recommendations and more.

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#TED #TEDTalks #TEDIntersections

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11 Comments

11 Comments

  1. @LoriMcalroy

    September 23, 2025 at 11:01 am

    Hey Ted 👋

  2. @LoriMcalroy

    September 23, 2025 at 11:04 am

    This couldn’t be more needed trauma n stress anxiety’s my middle name can’t believe im still here

  3. @LoriMcalroy

    September 23, 2025 at 11:07 am

    I was thinking this yesterday when it came to ibs and gastrics problems

  4. @Leto2ndAtreides

    September 23, 2025 at 12:09 pm

    What drug did you use for your Castleman disease?

  5. @TheBestLifeMindsetWithShelly

    September 23, 2025 at 1:24 pm

    Inspiring conversation! I love the focus on turning hope into concrete action, such a powerful reminder that small, consistent steps create real change. 💖

  6. @claires9100

    September 23, 2025 at 1:27 pm

    Holding despair and hope together is a very powerful concept. Hope in action is so important. This really resonates with me .

  7. @MaiAnnChan

    September 23, 2025 at 2:58 pm

    Truly inspiring story,just what my nephew is doing in Toronto, Canada, smart man❤❤❤❤❤

  8. @MaiAnnChan

    September 23, 2025 at 2:59 pm

    Great for those who are able to give their own TED talk❤❤❤❤😊🎉🎉❤❤

  9. @innerrise.official

    September 23, 2025 at 7:58 pm

    It’s truly inspiring to hear how two incredible individuals are turning hope into tangible action, tackling massive challenges in healthcare and social systems.

  10. @todaycountsshow

    September 24, 2025 at 4:39 am

    Holding hope and despair together fuels resilience, purpose, and meaningful impact. 🌱

  11. @KkKk-t2c7d

    September 24, 2025 at 6:30 am

    My friend, I find that formal British English, like what we hear on the BBC, is clear and beautiful. But I also understand that it’s important to learn both formal and casual English at the same time.

    The challenge is that British casual English feels very difficult for me, and there are so many different regional accents.

    So my question is: would it be acceptable to focus on formal British English, while also learning American casual English? I feel that American casual English is much easier to follow than British casual English.!

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People & Blogs

Monarch butterfly migrations are a spectacle — and a key indicator of ecosystem health #TEDTalks

When monarch butterflies migrate, they produce one of the most iconic wildlife spectacles in the world — and provide us with an important indicator of ecological health, says photographer Jaime Rojo. Telling a story about our relationship to the natural world, he shares his experience photographing these mesmerizing insects deep in their remote mountain habitats…

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When monarch butterflies migrate, they produce one of the most iconic wildlife spectacles in the world — and provide us with an important indicator of ecological health, says photographer Jaime Rojo. Telling a story about our relationship to the natural world, he shares his experience photographing these mesmerizing insects deep in their remote mountain habitats in Mexico, diving into the latest research into the mysteries of their multi-thousand-mile journey and sharing how each of us can join the growing movement to protect them.

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The Problem with Billionaires — and the Debut of True Net Worth | Randall Lane | TED

As chief content officer of Forbes, Randall Lane oversees the magazine’s signature list of billionaires, tracking the richest people on Earth. But he has noticed that this prompts the ultra-wealthy to stockpile their money instead of spending it on the public good. He debuts a new ranking — True Net Worth — that applauds billionaires…

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As chief content officer of Forbes, Randall Lane oversees the magazine’s signature list of billionaires, tracking the richest people on Earth. But he has noticed that this prompts the ultra-wealthy to stockpile their money instead of spending it on the public good. He debuts a new ranking — True Net Worth — that applauds billionaires for their philanthropy and rewards generosity. Guess who’s in the top five? (Recorded at TED2026 on April 16, 2026)

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The TED Talks channel features the best talks and performances from the TED Conference, where the world’s leading thinkers and doers give the talk of their lives in 18 minutes (or less) — plus originals, podcasts and exclusive content. Look for videos on Technology, Entertainment and Design as well as science, business, global issues, the arts and more. Visit for our entire library, transcripts, translations and personalized recommendations.

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#TED #TEDTalks #Economics

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The 6 Eras of NBA Fashion — from Restrained to Radical | Mitchell S. Jackson | TED

What are you wearing, and why? This is the question that writer and TED Fellow Mitchell S. Jackson asks as he unpacks the six eras of NBA style. Tracing an arc from Bill Russell to Lebron James and beyond, he explores how players use fashion on and off the court to challenge the limits placed…

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What are you wearing, and why? This is the question that writer and TED Fellow Mitchell S. Jackson asks as he unpacks the six eras of NBA style. Tracing an arc from Bill Russell to Lebron James and beyond, he explores how players use fashion on and off the court to challenge the limits placed upon them — revealing a deeper story about culture, identity and power. (Recorded at TEDNext 2025 on November 11, 2025)

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The TED Talks channel features talks, performances and original series from the world’s leading thinkers and doers. Subscribe to our channel for videos on Technology, Entertainment and Design — plus science, business, global issues, the arts and more. Visit to get our entire library of TED Talks, transcripts, translations, personalized talk recommendations and more.

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TED’s videos may be used for non-commercial purposes under a Creative Commons License, Attribution–Non Commercial–No Derivatives (or the CC BY – NC – ND 4.0 International) and in accordance with our TED Talks Usage Policy: . For more information on using TED for commercial purposes (e.g. employee learning, in a film or online course), please submit a Media Request at

#TED #TEDTalks #Fashion

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