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How Do You Turn Setbacks Into Motivation? A Doctor + A Trauma Specialist Answer | TED Intersections

How do you hold on to hope while still being realistic about the work that needs to be done? Immunology researcher David Fajgenbaum and public health expert Celina de Sola discuss how they scaled personal missions into organizations making long-term impact on communities near and far. They explore how to stay motivated, discover your leadership…

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How do you hold on to hope while still being realistic about the work that needs to be done? Immunology researcher David Fajgenbaum and public health expert Celina de Sola discuss how they scaled personal missions into organizations making long-term impact on communities near and far. They explore how to stay motivated, discover your leadership style and uncover overlooked solutions hiding in plain sight. (This conversation is part of “TED Intersections,” a series featuring thought-provoking conversations between experts navigating the ideas shaping our world.)

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11 Comments

11 Comments

  1. @LoriMcalroy

    September 23, 2025 at 11:01 am

    Hey Ted 👋

  2. @LoriMcalroy

    September 23, 2025 at 11:04 am

    This couldn’t be more needed trauma n stress anxiety’s my middle name can’t believe im still here

  3. @LoriMcalroy

    September 23, 2025 at 11:07 am

    I was thinking this yesterday when it came to ibs and gastrics problems

  4. @Leto2ndAtreides

    September 23, 2025 at 12:09 pm

    What drug did you use for your Castleman disease?

  5. @TheBestLifeMindsetWithShelly

    September 23, 2025 at 1:24 pm

    Inspiring conversation! I love the focus on turning hope into concrete action, such a powerful reminder that small, consistent steps create real change. 💖

  6. @claires9100

    September 23, 2025 at 1:27 pm

    Holding despair and hope together is a very powerful concept. Hope in action is so important. This really resonates with me .

  7. @MaiAnnChan

    September 23, 2025 at 2:58 pm

    Truly inspiring story,just what my nephew is doing in Toronto, Canada, smart man❤❤❤❤❤

  8. @MaiAnnChan

    September 23, 2025 at 2:59 pm

    Great for those who are able to give their own TED talk❤❤❤❤😊🎉🎉❤❤

  9. @innerrise.official

    September 23, 2025 at 7:58 pm

    It’s truly inspiring to hear how two incredible individuals are turning hope into tangible action, tackling massive challenges in healthcare and social systems.

  10. @todaycountsshow

    September 24, 2025 at 4:39 am

    Holding hope and despair together fuels resilience, purpose, and meaningful impact. 🌱

  11. @KkKk-t2c7d

    September 24, 2025 at 6:30 am

    My friend, I find that formal British English, like what we hear on the BBC, is clear and beautiful. But I also understand that it’s important to learn both formal and casual English at the same time.

    The challenge is that British casual English feels very difficult for me, and there are so many different regional accents.

    So my question is: would it be acceptable to focus on formal British English, while also learning American casual English? I feel that American casual English is much easier to follow than British casual English.!

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People & Blogs

Why You Should Keep a List of What Makes You Laugh | Chris Duffy | TED

The world is weird and hilarious — if you know where to look, says comedian Chris Duffy. In conversation with “TED Talks Daily” host Elise Hu, Duffy breaks down three practical pillars of humor, showing how laughter can help you feel present, creative and connected, even when the world feels overwhelming.(Recorded atTED Talks Daily Book…

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The world is weird and hilarious — if you know where to look, says comedian Chris Duffy. In conversation with “TED Talks Daily” host Elise Hu, Duffy breaks down three practical pillars of humor, showing how laughter can help you feel present, creative and connected, even when the world feels overwhelming.(Recorded atTED Talks Daily Book Club on February 18, 2026)

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#TED #TEDTalks #Humor

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What happens when you invite @MarkRober to give a TED Talk? He blows something up, of course! #TED

Mark Rober spent years trying to land a rover on Mars. Now, the former NASA engineer turned science YouTuber with millions of subscribers is launching a new mission: to teach the next generation of big problem solvers. That’s why he’s spending 60 million dollars to build a STEM curriculum kids actually want. With squirrel obstacle…

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Mark Rober spent years trying to land a rover on Mars. Now, the former NASA engineer turned science YouTuber with millions of subscribers is launching a new mission: to teach the next generation of big problem solvers. That’s why he’s spending 60 million dollars to build a STEM curriculum kids actually want. With squirrel obstacle courses, giant lasers and elephant toothpaste explosions, who wouldn’t want to learn from YouTube’s top engineer?

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The Fleeting Euphoria of Success | Debbie Millman | TED

Over two decades of interviewing countless creative people, Debbie Millman (host of the iconic “Design Matters” podcast) had a realization: the pride and joy of accomplishing something often evaporates almost instantly. She explains how to stop chasing external validation for your achievements and instead live for the act of creation itself. (Recorded at TEDNext 2025…

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Over two decades of interviewing countless creative people, Debbie Millman (host of the iconic “Design Matters” podcast) had a realization: the pride and joy of accomplishing something often evaporates almost instantly. She explains how to stop chasing external validation for your achievements and instead live for the act of creation itself. (Recorded at TEDNext 2025 on November 9, 2025)

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The TED Talks channel features the best talks and performances from the TED Conference, where the world’s leading thinkers and doers give the talk of their lives in 18 minutes (or less) — plus originals, podcasts and exclusive content. Look for videos on Technology, Entertainment and Design as well as science, business, global issues, the arts and more. Visit for our entire library, transcripts, translations and personalized recommendations.

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#TED #TEDTalks #Creativity

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