What do you do when the world declares something impossible? When physician-scientist David Fajgenbaum was dying from a rare disease and social entrepreneur Kiah Williams was confronting the realities of economic hardship, they began asking a different question: What can I do today? In this conversation, they discuss how turning hope into action can drive meaningful change — one step at a time. (This conversation is hosted by The Audacious Project’s Alexandra Tillmann) (Recorded at TEDNext 2025 on November 10, 2025.)

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