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Maintaining Momentum and Morale while Seeking FDA Approval l Build Mode

Surviving the long road to FDA approval isn’t just about building great technology, it’s about keeping your team motivated, finding the right investors, and learning how to operate when timelines are uncertain. This week on Build Mode, Isabelle Johannesen sits down with Robbie Bustami, co-founder and CEO of BioticsAI, a Startup Battlefield-winning company building an…

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Surviving the long road to FDA approval isn’t just about building great technology, it’s about keeping your team motivated, finding the right investors, and learning how to operate when timelines are uncertain.

This week on Build Mode, Isabelle Johannesen sits down with Robbie Bustami, co-founder and CEO of BioticsAI, a Startup Battlefield-winning company building an AI copilot for ultrasound to help detect fetal abnormalities. From a $100K prototype to FDA clearance, Robhy shares what it actually takes to build in one of the most regulated industries in the world.

In this episode, they break down what it really looks like to build a medtech startup, where you can’t “move fast and break things,” and every milestone takes time, coordination, and trust.

This conversation covers:

• How to stay motivated and keep your team aligned when FDA approval isn’t guaranteed

• What founders need to know about navigating the FDA process from day one How to find investors who understand the slower, high-risk nature of medtech

• Why cross-functional collaboration (engineers, clinicians, researchers) is critical to success

• The role of advisors and why active industry experts matter more than big names

• How to build momentum and celebrate wins during long, uncertain timelines

 Subscribe to Build Mode on Apple Podcasts () , Spotify () , or wherever you like to listen () . And watch the full videos on YouTube () .

Apply to Startup Battlefield: We are looking for early-stage companies that have an MVP. So nominate a founder (or yourself): techcrunch.com/apply () . Be sure to say you heard about Startup Battlefield from the Build Mode podcast.  

TechCrunch Disrupt: ([%E2%80%A6]pt2026&utm_content=ticketsales&promo=buildmode15&display=true) If you’re thinking about applying to Startup Battlefield, then October 13 to 15 in San Francisco, we’re back for TechCrunch Disrupt, where the Startup Battlefield 200 takes the stage. So if you want to cheer them on, or just network with 1000s of founders, VCs, and tech enthusiasts, then grab your tickets. ([%E2%80%A6]pt2026&utm_content=ticketsales&promo=buildmode15&display=true)  

Use code buildmode15 for 15% off any ticket type. 

Chapters:

00:00 Building a $100K MedTech Startup

00:32 Intro: Biotics AI & the Problem with Ultrasound Misdiagnosis

02:16 What Biotics AI Actually Does (AI Copilot for Ultrasound)

02:54 Early Days: Startup Battlefield & First Product

07:10 Navigating FDA Approval (Without Guesswork)

09:22 What FDA Clearance Unlocks (Going to Market)

10:59 Selling into Hospitals & Early Customers

12:11 Keeping a Team Motivated During Long Timelines

18:54 The Hardest Parts of Building in MedTech

22:22 Fundraising, Advisors, and Building the Right Team

28:33 The Future of AI in Reproductive Healthcare

New episodes of Build Mode () drop every Thursday. Hosted by Isabelle Johannessen. Produced and edited by Maggie Nye. Audience development led by Morgan Little. Special thanks to the Foundry and Cheddar video teams.

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Science & Technology

Why this CEO thinks video games make better training data than the internet | Equity Podcast

When it comes to achieving artificial general intelligence (AGI), large language models just don’t have what it takes. Models like ChatGPT and Claude are great at text, but they’re less skilled at understanding how things actually move through space and time — an essential skill for producing intelligence that generalizes. That gap, it turns out,…

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When it comes to achieving artificial general intelligence (AGI), large language models just don’t have what it takes.

Models like ChatGPT and Claude are great at text, but they’re less skilled at understanding how things actually move through space and time — an essential skill for producing intelligence that generalizes. That gap, it turns out, might be filled by gaming data. That’s the bet behind General Intuition, a Bezos-backed, New York-based startup valued at $2.3 billion that just closed a $320 million round with Coatue, Eric Schmidt, and researchers at MIT and Google DeepMind joining its list of investors.

On this episode of TechCrunch’s Equity podcast, General Intuition CEO Pim de Witte joins Rebecca Bellan to dig into why world models trained on gaming data might be the next big leap in physical AI, how the company spun out of gaming platform Medal TV, and where the ethical red lines are when your models could end up being used for defense applications.

Subscribe to Equity on YouTube, Apple Podcasts, Overcast, Spotify and all the casts. You also can follow Equity on X and Threads, at @EquityPod.

Chapters
00:00 Intro
1:04 General Intuition’s $320M round and its star-studded backers
2:23 Pre-training on games instead of text
6:02 Medal TV’s proprietary data and real-world robotics demo
9:38 Turning down an OpenAI acquisition offer to build a generational company
11:05 The co-founders behind the DIAMOND world model paper
14:11 Finding data gold beyond gaming, and why YouTube video falls short
19:44 Defense red lines, ethics, and building jobs through Nerve
25:46 Outro

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Science & Technology

How Algorithms Manipulate You (and How to Fight Back) | Idea Knock Down | TED

What does it take to stay in control of your life online? AI ethicist Jen Golbeck and TED Fellow Shalini Kantayya discuss how algorithms, data collection and AI shape the choices you make every day. They explore whether it’s possible to use the internet without giving up your privacy, how to push back against big…

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What does it take to stay in control of your life online? AI ethicist Jen Golbeck and TED Fellow Shalini Kantayya discuss how algorithms, data collection and AI shape the choices you make every day. They explore whether it’s possible to use the internet without giving up your privacy, how to push back against big tech and what AI should never be allowed to decide. (This episode is part of “Idea Knock Down,” a series featuring experts with different perspectives taking on big questions — one block at a time.) (Recorded on June 12, 2026)

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The TED Talks channel features the best talks and performances from the TED Conference, where the world’s leading thinkers and doers give the talk of their lives in 18 minutes (or less) — plus originals, podcasts and exclusive content. Look for videos on Technology, Entertainment and Design as well as science, business, global issues, the arts and more. Visit for our entire library, transcripts, translations and personalized recommendations.

TED videos may be used for non-commercial purposes under a Creative Commons License, Attribution–Non Commercial–No Derivatives (or the CC BY – NC – ND 4.0 International) and in accordance with the TED Talks Usage Policy: . For more information on using TED for commercial purposes (e.g. employee learning, in a film or online course), submit a request at

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Science & Technology

Build Mode: Inside the Fundraise

Startup fundraising is harder than ever, and Season 3 of Build Mode is here to help. Whether you’re raising a seed round, preparing for Series A, pitching venture capital firms, negotiating a term sheet, or exploring alternatives to VC funding, this season is packed with practical advice from founders and investors who have successfully navigated…

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Startup fundraising is harder than ever, and Season 3 of Build Mode is here to help. Whether you’re raising a seed round, preparing for Series A, pitching venture capital firms, negotiating a term sheet, or exploring alternatives to VC funding, this season is packed with practical advice from founders and investors who have successfully navigated the fundraising journey.

Hosted by TechCrunch Startup Battlefield Editor Isabelle Johannessen, Build Mode is the TechCrunch podcast where founders, investors, and startup operators share honest conversations about what it really takes to build and finance a company. This season features Charles Hudson (Precursor Ventures), Andrew Dai (Elorian), Ashley Tyrner-Dolce (FarmboxRx), Kristina Subbotina (Lexsy AI), Sydney Sykes (NVIDIA), Xavier Chi (Mbodi), Jack Groetzinger (SeatGeek), Sasha Orloff (Puzzle), Everette Taylor (Kickstarter), Manan Mehta (Unshackled Ventures), Julia Hartz (Eventbrite), and more. Together, they cover topics including avoiding down rounds, raising capital in today’s venture market, working with corporate venture capital, crowdfunding, startup financial readiness, fundraising as an immigrant founder, IPO lessons, and how to deliver a winning startup pitch.

If you’re an entrepreneur, startup founder, investor, or operator looking for actionable fundraising advice, this season is your playbook. New episodes begin July 9 and release every week on YouTube, Spotify, Apple Podcasts, and wherever you listen to podcasts. Subscribe now and learn how to raise capital, grow your startup, and build with confidence.

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