Science & Technology
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The idea that depression comes from a chemical imbalance in the brain has shaped treatment for decades. Neuroscientist Lisa Monteggia shares research suggesting that’s not the whole story — and shows how a decades-old drug could upend what we thought we knew about depression, with the potential to offer relief within hours. (Recorded at TEDxNashvilleWomen…
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@harrypearle9781
August 16, 2026 at 12:29 pm
TIME backwards is EMIT (It takes TIME to EMIT positive responses)
=========================================================
This research might work better, with common sense ideas about TIMING, etc
(Slow and steady, wins the race, Aesop) Life is fast paced, but we can slow down some) Much thanks
@FredtheBudgie
August 16, 2026 at 12:37 pm
Is this why it’s such a draw for our kids to abuse it. It’s a massive issue in U.K. it’s damages the bladder long term!
@harrypearle9781
August 16, 2026 at 12:41 pm
TRUMP and the RIGHT?
===================
What does this work on Depression suggest to help us cope with NEGATIVE politics, now? thanks much
@pablosmitty4024
August 16, 2026 at 11:06 pm
@harrypearle9781 start with not ruminating. Focus on gratitude
@rishiaman2
August 16, 2026 at 12:47 pm
0:21 meds currently there is just suppressant..only deals with symptoms and not the root cause
@pfennigsworth
August 16, 2026 at 6:08 pm
Lots of meds are used specifically to treat symptoms. Morphine or ibuprofen won’t fix a broken leg, but they make living with a broken leg a lot easier.
@MrOlleyOlley
August 17, 2026 at 4:19 am
@pfennigsworthbut do they make people keep on walking on the broken leg?
That is what antidepressants seem to do to lots of people. Make it easier to keep on living the life that makes you depressed.
@SeedsForYourMind
August 16, 2026 at 12:49 pm
My love, your advice is so important to get out there today with so many – in fact, most people – having flawed, outdated information going with the debunked chemical imbalance theories thanks to the anti-scientific abomination that is known as the DSM by the psychiatry industry. It’s time to go with updated science!
@andreasgruber7534
August 16, 2026 at 1:02 pm
Hört sich an als wäre sie eine Pharmareferentin
@beatricetheves-engelbach8074
August 16, 2026 at 2:21 pm
Try art therapy, fall in love, sit by a river, read the tao philosophy, find a good yoga teacher. There’s nothing like being in deep contact with nature to feel energy.
Once you get it, slowly get rid of drugs. They harm you with side-effects.
@beatricetheves-engelbach8074
August 16, 2026 at 2:38 pm
and above all, be yourself. Not the one others would like you to be. Find your roots and your sky, relate them
@gazzam3172
August 16, 2026 at 5:39 pm
whats an ssri?
@akandeelizabeth2963
August 16, 2026 at 5:58 pm
Selective Serotonin Receptor Inhibitor.
@davidb2206
August 17, 2026 at 10:42 am
The drug that all the mass shooters are on in the USA, but the media won’t mention it.
@pfennigsworth
August 16, 2026 at 7:01 pm
I’m 75. I’ve had depression since before I was out of high school, and have taken a slew of antidepressants over the years, with varying results. Ketamine and psilocybin have completely transformed our understanding of depression and the neural pathways that maintain and reinforce depression. Rumination, the self-defeating, endlessly repeating self-talk that is so much a part of depression resides in the “Default Mode Network,” the part of the brain active when you’re not involved in productive thought or engaged in the world outside of yourself.
The neuroplasticity Dr. Monteggia speaks of disrupts the default mode network, essentially telling those neurons to stop hanging around with the same old crowd, and it allows them to communicate with a different crowd, circuits that they usually don’t communicate with. The problem, which she also speaks of, is that the results don’t last. I think therapy is required to optimize the results of ketamine and psilocybin. The chemistry allows plasticity, creates a window of opportunity to re-program (de-program?) the default mode network. Reconstructing how one refers to oneself, I think, will be key to long-lasting results.
@raylow9878
August 16, 2026 at 7:22 pm
fluxotine works wonder for me at 20 mg.
@rishiaman2
August 18, 2026 at 7:40 pm
Only treats symptoms. Eventually u have to increase ur dosage, cs ur receptors get immune to current dosage
@anotherdave1039
August 16, 2026 at 7:47 pm
Weird idea, a pill that has ketamine, THC, and amphetamine, but all at low therapeutic dose and well below recreational dose. Take it and go have fun with a group of friends. The time with friends is the treatment, the medication is to make the treatment more effective and long-lasting.
@AdamKrzysztofPawlowski
August 17, 2026 at 3:26 am
It took me a second to get the joke – good one, Sir 😀
@LuisOtten-q8w
August 16, 2026 at 7:52 pm
Because people have been fed misinformation for the sake of profit to the pharma industry.
Depression is due to lack of protons – bad diet-.
@KaleemUllah8676ak
August 17, 2026 at 3:29 am
For anyone who constantly feels overwhelmed, tense or mentally exhausted, Clara Hartley’s anxiety quiz could be a useful place to start. It only takes a few minutes.
@AdamKrzysztofPawlowski
August 17, 2026 at 3:29 am
I am very sorry to this Lisa Miss, but she is a terrible speaker and, like someone said, blue era in Picasso was because it was the cheapest paint not because he was depressed – he was piss poor at that moment. However yes – there is a lot of new studies showing serotonine increase is not the only or not even the main avenue of treatment for depression – it might really have everything to do with neuroplasticity increase because glutamate inhibition but also BDNF factor increase drugs (peptides like Semax, Selank) have this potential by acting on other levers of neuroplasticity.
@CureFrontier
August 17, 2026 at 6:03 am
Self-care isn’t selfish; it’s essential for a happy life.
@azim99k
August 17, 2026 at 8:42 am
Not me searching for Sara Rivers arche type quiz after seeing it mentioned three times today. I don’t even normally do these quizzes. The curiosity got me.
@davidb2206
August 17, 2026 at 10:44 am
Drugs are not the answer. Depression is inactivity. It is a symptom created by the leisure and welfare state in modern times. The cure is activity, that is, more WORK. If you are WORKING 100 hours per week, as I have done, I guarantee you will be too tired to even think about “depression.” Work more. And work HARD.
@MehjabinPriya-e8f
August 17, 2026 at 10:46 am
helpful ❤
@one234569and10
August 17, 2026 at 10:55 am
Depression is not all about serotonin though. I mean, what happens to people with p?T s d or people that have been raped oor attacked or whatever… that is not a serotonin imbalance that’s trauma.And trauma can cause depression
@zerojee1
August 17, 2026 at 11:04 am
If so many people need to alter their brain chemistry in order to cope with our current modern society – maybe taking more pills is not the answer.
@jillk1973
August 17, 2026 at 11:20 am
I wish it were affordable. I’m 53 and have been on antidepressants since I was 13. Had ECT, lengthy hospitalizations and currently take 3 different meds. I don’t know what a healthy brain feels like and would like to try this but make less than 25k a year and could never afford it. I hope the price comes down significantly someday
@annmiracle4872
August 18, 2026 at 2:52 pm
I would look into Spravato. Insurance will probably pay for it. If not Spravato (esketamine) is made by Janssen Pharmaceuticals, which is the pharmaceutical division of Johnson & Johnson the pharmaceutical division of Johnson & Johnson and they have financial help for those who qualify. Definitely check it out. It saved my life and I’ve tried everything available to me. Amazing stuff. You would still have to pay for monitoring which can be expensive but it’s definitely better. You would have to go often in the beginning but I was one time weekly. Now I am going 2-3 weeks between treatments. Good luck! Access to these types of meds is improving quickly so don’t give up hope.
@akaDustyn
August 17, 2026 at 2:47 pm
Number Needed to Treat (NNT) is an epidemiological measure representing the average number of patients who must be treated to prevent one additional adverse outcome or achieve one additional beneficial outcome. It is calculated as the inverse of the Absolute Risk Reduction (ARR):
NNT= ARR/1
Where ARR is the difference between the event rate in the control group ( CER ) and the event rate in the experimental group ( EER ):
ARR=CER−EER
Thanks ai -Jesus
@Blizzhobbs
August 17, 2026 at 3:19 pm
I have used ketamine and other dissociatives recreationally when I was younger. It certainly has a strong after-glow or antidepressant effect. But it only last for about a week or two. It’s only a temporary effect that needs to be combined with therapy and lifestyle changes in order to be truly effective.
Tons of neurotransmitters and hormones affect mood and emotion regulation. But the connectivity between certain brain regions does as well, among other things we have little understanding of. Exercise in particular promotes BDNF release which causes synaptogenesis thus alleviating depression.
@ShawnLH88
August 17, 2026 at 6:24 pm
….mdma is a known therapy to help depression and ptsd ….
😊
@user-hn2jp9kp5g
August 18, 2026 at 2:24 am
❤🎉
@aibonewt
August 18, 2026 at 6:21 am
Run
@christianherrmann
August 18, 2026 at 4:43 pm
Wow, AI SLOP IN TED. Hey TED how low can you still go? I guess you really want to find out
@christianherrmann
August 18, 2026 at 4:47 pm
Boring long winded speech with information that could be said in less than 5min in detail.
@rishiaman2
August 18, 2026 at 7:40 pm
Summary: long ket promoting ad
@WatchfulHunter
August 18, 2026 at 8:01 pm
Hope cures depression. A way out. Escape. Freedom. Simple joyful dialog and changing our perspective cures depression.
No drugs needed.
People need hope.
And we need to care about the depressed. Encourage them.
Have fun together.
Go places together.
The drug industry is predatory.
They see our problems as opportunity to profit.
Like any street drug dealer.
For me, my endless joy comes from knowing I have a very real, though spiritual Creator who cares about me. My love, hope and happiness comes from Him. I lift people up. I encourage them.
@attahaas
August 19, 2026 at 4:29 am
Poor editing work, the slide presentation was almost completely missed throughout the video and was only shown sporadically at bad angles!
@ErinNino
August 19, 2026 at 12:30 pm
This is how I was cured:
I named the people that had hurt me and what they did out loud each time I felt depressed and I said I forgive you.
Then I asked God to show me when and how I had hurt others and I repented.
I did this daily for two months and continue to do this weekly. I no longer suffer from lifelong depression. ❤
@Jeremiah-h8i
August 19, 2026 at 2:01 pm
I think SSRIs are basically a scam
@avicohen2k
August 19, 2026 at 2:54 pm
Opioids also works fast, doesn’t mean it’s a long term treatment.
@TzadikTheManic
August 19, 2026 at 3:23 pm
Was hoping it was about something more obscure/or new. I have 8 treatment-resistant comorbid disorders, have taken 150+ meds, ketamine, tms, ect, as well as others (cbt, dbt, iop’s etc). I haven’t had a single truly bearable day in years. -Except, actually – a full week of insomnia recently made me feel like ME again.. lasted barely an entire day 😔 If it wasn’t so unhealthy I’d use sleep deprivation as a (desperate) solution. Ketamine helped briefly, but only the IV and only for under a week. Too expensive to remain happy in any sense .
@minimaxhall
August 19, 2026 at 5:43 pm
Depression is exactly what you think. If you didn’t think / or had no thought. You wouldn’t be depressed. If you were an earthworm you would be fine.
@hebbelille7828
August 19, 2026 at 6:53 pm
5:25 Between high anestetic dose and depression treatment dose, it’s not a party drug. That would be a slumber party.
@hebbelille7828
August 19, 2026 at 7:04 pm
5:40 Effect after hours is not very common. Most experience effect after 3 or more treatments, the first 2 are lower doses.
@hebbelille7828
August 19, 2026 at 7:13 pm
10:57 Effect doesn’t last just a few days for most, it can last for weeks or months, years. For me, 5 weeks, after months of treatment.