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How COVID-19 human challenge trials work — and why I volunteered | Sophie Rose

Visit to get our entire library of TED Talks, transcripts, translations, personalized talk recommendations and more. In April 2020, epidemiologist-in-training Sophie Rose volunteered to be infected with the virus that causes COVID-19. As a young, healthy adult, she’s offering to take part in a human challenge trial, a study where participants are intentionally exposed to…

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Visit to get our entire library of TED Talks, transcripts, translations, personalized talk recommendations and more.

In April 2020, epidemiologist-in-training Sophie Rose volunteered to be infected with the virus that causes COVID-19. As a young, healthy adult, she’s offering to take part in a human challenge trial, a study where participants are intentionally exposed to SARS-CoV-2 to test vaccines and gather critical data. Explaining how challenge trials could speed up the development of effective vaccines, Rose shares why volunteering was the right decision for her.

The TED Talks channel features the best talks and performances from the TED Conference, where the world’s leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design — plus science, business, global issues, the arts and more. You’re welcome to link to or embed these videos, forward them to others and share these ideas with people you know.

TED’s videos may be used for non-commercial purposes under a Creative Commons License, Attribution–Non Commercial–No Derivatives (or the CC BY – NC – ND 4.0 International) and in accordance with our TED Talks Usage Policy (). For more information on using TED for commercial purposes (e.g. employee learning, in a film or online course), please submit a Media Request at

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92 Comments

92 Comments

  1. Martin Svensson

    December 1, 2020 at 9:39 pm

    TED has to stop promoting the covid scam and going along with this agenda.. Or I’m pretty sure you are going to end up on a list for future trials.

    • Mateo

      December 1, 2020 at 11:08 pm

      Pandemic ther is propaganda and lie

    • suddenlybananas

      December 2, 2020 at 12:27 am

      Go sue them you brave warrior. I’m sure they will be scared shitless. 😀

  2. 0 0

    December 1, 2020 at 9:41 pm

    I will never take that vaccine. The virus will mutate, the long term ailments of the vaccine. Why would anyone inject themselves with something foreign their body? Why not stop it using logic and if we all stay at home until it ends, no more virus will be around!

    • A. Mae

      December 1, 2020 at 11:06 pm

      @Sentient Tent sure all that is true, but people are still dying from it. Despite being less contagius than covid, despite the vaccines. People are STILL dying(in numbers) each year. Not to mention these vaccines are a complete joke. My dad got a shot last year and funny enough caught quite a bad flu a week after the shot. Mind you the last time he had the flu was 20years ago. Im not saying the vaccine had anything to do with him catching the flu, its just funny because it made zero difference whatsoever.

    • A. Mae

      December 1, 2020 at 11:08 pm

      @Jim Bagheed What is wrong with you?

    • A. Mae

      December 1, 2020 at 11:08 pm

      @Jim Bagheed You never heard of a real person with a different opinion than yours? What are you 5?

    • Jim Bagheed

      December 1, 2020 at 11:13 pm

      @A. Mae definitely something a bot would say. Spreader of misinformation, why you watching Ted talks? Didn’t think your sort were into facts. Oh wait you’re still pedalling BS like the other bots on here 😂

    • A. Mae

      December 1, 2020 at 11:26 pm

      @Jim Bagheed You are actually delusional. You can dehumanize me all you want it does not change the fact that there are plenty of people in this world who have complete opposite opinion of yours. Yeah unfortunately to you i can speak my mind freely and express my opinions and beliefs. This is called democracy, what you are talking about is more close to fascism than anything.

  3. topwelda147

    December 1, 2020 at 9:41 pm

    And the Oscar goes to 🥁 🥁 🥁 this shill 👏 Stick ur vaccine where sun don’t shine

  4. Martin Svensson

    December 1, 2020 at 9:45 pm

    No 1 question people need to start asking themsleves: Since there is nothing pointing at there even existing a virus other than the regular influenza… why are those in power so desperate to get people vaccinated? Since they never cared about human lives before.. especially not when bombing other contries to total destruction to get their agenda going. And now the same group of people wants to inject you with something that is not supposed to be in your body… from corporations that make money off of people being sick.. What could possible be wrong lol.
    Are people this stupid for real?

  5. Catchy Experiments

    December 1, 2020 at 9:47 pm

    RANDOM FACT: May was once considered an incredibly ill-omened time to get married. There’s an adage for it actually, which goes: “Marry in May and you’ll rue the day”. It’s not clear where exactly the saying comes from, but there must have been a pretty good reason to not get married in one of the most beautiful months of the year! 😎

  6. hpod3sx

    December 1, 2020 at 9:47 pm

    Vaccines need to be tested for years, not months…

  7. James Kulevich

    December 1, 2020 at 9:48 pm

    80% will feel nothing (no symptoms). 18% will have mild to severe symptoms. 1 1/2 to 2% will die. They’re blowing out of proportion.

  8. James Kulevich

    December 1, 2020 at 9:57 pm

    There ISN’T anything extraordinary about Covid-19. Since all contagions must pass through the population at least once, it’s only that power over humans is that your immune system doesn’t recognize it. Once you’ve had it, your immune system will recognize it and create antibodies. It’ll fissile out.

    • Sentient Tent

      December 2, 2020 at 12:04 am

      Well that’s the point of a vaccine, to pass resistance to a contagion without the loss of life and function from having large populations being subjected to the disease.

  9. JRESHOW

    December 1, 2020 at 9:58 pm

    Maybe focus on eliminating things like genetically modified food, herbicides sprayed on organic food, hormonal inflamed animals working non-stop in concentration camps to produce more depressed meat, chemtrails sprayed above our head, rid soda, cigarettes, and alcohol, promote an actual healthy diet, stop using the general public as test rats for your witchcraft pills and dna/rna altering vaccines. Let’s get to the root of things friends, what they’re doing here is the end. Their complete logic and common sense is corrupt or they aren’t who they say they are, most likely both.

    • suddenlybananas

      December 2, 2020 at 12:23 am

      Ah, yeah, that will help combat the current pandemic.Thank you for your brilliant insights. 👍

    • JRESHOW

      December 2, 2020 at 12:53 am

      @suddenlybananas if it were about health and keeping people alive, yea.

    • suddenlybananas

      December 2, 2020 at 12:57 am

      @JRESHOW Sure, sure, it’s all a huge conspiracy. 😉

    • JRESHOW

      December 2, 2020 at 1:01 am

      @suddenlybananas 👍🏼

  10. Amber Lasater

    December 1, 2020 at 10:04 pm

    Thank you for being a volunteer. You are so brave. I understand what you are saying about if family needs then you are willing to help your loved one. I feel exactly the same way. As soon as the vaccine comes to the USA I am getting my vaccination. I want to make sure that I am ok to finally spend time with my family, and friends, and those around me.

  11. ga b1

    December 1, 2020 at 10:31 pm

    As long you don’t force people to take the vaccine, everything will be alright, I promise…

  12. Nicole Mongilardi

    December 1, 2020 at 10:45 pm

    Thank you so much Sophie! It is so refreshing to see that level of kindness and selflessness.

    • JRESHOW

      December 2, 2020 at 12:06 am

      Joined 9 years ago and only left one comment today, on this video? Outstanding coincidence!

    • suddenlybananas

      December 2, 2020 at 12:19 am

      @JRESHOW Only the people agreeing with your conspiracy “facts” are real, of course! HOW ELSE CAN IT BE :O

    • JRESHOW

      December 2, 2020 at 1:01 am

      @suddenlybananas look at cha. Bot.

  13. creative source

    December 1, 2020 at 10:57 pm

    Has she got an Australian accent? I cant place it.

    • SilverSkylark

      December 2, 2020 at 1:07 am

      Yes

  14. The Monopoly Guy

    December 1, 2020 at 11:04 pm

    Why would you get a man made vaccine to a man made virus. Sheeeeeeeep

    • suddenlybananas

      December 2, 2020 at 12:31 am

      It’s better to be a sheep with proof than a weirdo without any.

  15. Jade Choi - Million Dollar Challenge

    December 1, 2020 at 11:07 pm

    Thank you for your volunteer and your work

  16. SUB0DII

    December 1, 2020 at 11:12 pm

    people who give TED talks: smart, intelligent, profound

    people in the youtube comments for TED talks: tiny brain

    • Fabian Grasser

      December 2, 2020 at 12:02 am

      Ey cool u r also in the comments xD

    • Mac Ton

      December 2, 2020 at 1:00 am

      You clearly haven’t seen a lot of ted talks lmao

  17. Alli Morani

    December 1, 2020 at 11:38 pm

    No one should put this in there body

    • SilverSkylark

      December 2, 2020 at 1:10 am

      That’s why she’s a hero, because it’s still dangerous until confirmed safe.

  18. TwoXBe

    December 1, 2020 at 11:41 pm

    Did she get a lobotomy or maybe a side effect from the vaccine

  19. Jason M

    December 1, 2020 at 11:41 pm

    How much do you get….that’s what needs to be answered

  20. Spleen Mary

    December 1, 2020 at 11:42 pm

    Or people could just follow safety protocol for a year or two and wipe it out completely but nah you all need to go to cafes and shopping centres.
    Convenience and capitalism over everything, right? 🙄🙄🙄

    • Mac Ton

      December 2, 2020 at 1:02 am

      You have a much higher chance dying in a car accident on the way to restaurant than dying of this stupid virus, branch covidian.

  21. Elliott James

    December 2, 2020 at 12:15 am

    Bunch of bullshit

  22. Politifeast

    December 2, 2020 at 12:20 am

    Don’t believe anything this creature is saying to you.

    • Siofra:3

      December 2, 2020 at 12:34 am

      ???

  23. Politifeast

    December 2, 2020 at 12:21 am

    Nobody is waiting for your dirty vaccines.

  24. Corsair Cowboy

    December 2, 2020 at 12:43 am

    There is no Pandemic.
    There is no deadly virus.
    There is only the New World Order implementing their Agenda 21 plan (now rebranded as the “Great Reset” by The World Economic Forum)

    • SilverSkylark

      December 2, 2020 at 1:14 am

      They could have done a better job then.
      Why would they continue to target America so hard when a lot of other countries have stopped dying?

  25. Jordan Bergeron

    December 2, 2020 at 1:08 am

    They’ll put the propaganda everywhere they can!

    • SilverSkylark

      December 2, 2020 at 1:11 am

      If vaccines didn’t work, they wouldn’t have spent so much time making one. They would have just released a ‘vaccine’ after COVID became bad.

  26. Sumat

    December 2, 2020 at 6:45 am

    Thank you for being a volunteer. You are a legend!

  27. Natures Finest

    December 2, 2020 at 7:21 am

    Shorty trippin

  28. K-DRAMA GOODMORNING SEOUL

    December 2, 2020 at 7:37 am

    From yesterday, December, winter began.

    – A new week/month- I hope that garlic health and good things will be together. ^O^

  29. Duane Burns

    December 2, 2020 at 9:18 am

    Remember people, , flu vaccine been around for decades. it’s lucky if it’s 50% effective
    now they want inject everyone with a vaccine for a virus has a99% survival rate? Is everyone stupid ,
    – vaccine is a sterilization shot for everyone, except the rich

  30. xEmpty.Abyssx

    December 2, 2020 at 9:26 am

    Will Spanish subtitles be available soon?

  31. Alwyn Nito

    December 2, 2020 at 9:49 am

    off topic; WHY is every house in the world not equipped with an aquarium spa/bath that houses the organisms/viruses in the Ganges river to save on water?

  32. Chris J

    December 2, 2020 at 9:58 am

    Why doesn’t she seem at all human, makes me feel uneasy af😂

    • MAYBE HUMAN

      December 2, 2020 at 5:38 pm

      You have Intuition!

    • Chris J

      December 2, 2020 at 5:41 pm

      @MAYBE HUMAN ironic considering your name 😂

    • Chris J

      December 2, 2020 at 5:44 pm

      I can’t be the only one whom she makes feel very uneasy…

    • Stuart Cole

      December 3, 2020 at 1:25 pm

      It’s because it’s some one who is reading from a script who clearly is not used to doing it.

  33. david marilley

    December 2, 2020 at 10:46 am

    Too bad we are kept ignorant about Ivermectin. Global death count should match the March 1 cumulative total. That would have given us 10 billion tablets and Ro could be ZERO. She sure doesn’t know anything about IVERMECTIN. Some intensivists do. Hard for me to accept this ignorance embedded in this talk.

  34. david marilley

    December 2, 2020 at 10:47 am

    I’ll challenge at 65 y.o. No issue for me whatsoever

  35. Sven Carlin PHD

    December 2, 2020 at 11:10 am

    I had a lot of responsibilities to handlebar my monthly pay wasn’t enough thanks the God I was recommended to my trader ,Mr Peter schiff now I have been about trying binary options and it’s been successful ever since I started ,all thanks to Mr Peter

    • Sven Carlin PHD

      December 2, 2020 at 11:10 am

      ‪+44 7393 152637‬

  36. Joshua Eakridge

    December 2, 2020 at 11:34 am

    LOVE YOUR VIDEOS ❤️❤️ but Could this be a dream $7000 profits gotten with just a little investment of $750 after 24 hours of profits I highly recommend Mr Peter schiff he’s so exciting when it comes to trades and profit making .

    • Joshua Eakridge

      December 2, 2020 at 11:34 am

      ‪+44 7393 152637‬

    • Wenna Flokks

      December 2, 2020 at 11:35 am

      The freedom that comes when you met a professional pro-binary option trader like Mr Peter schiff (ultra forex admin) I’ll be forever grateful to you ,I send recommendations to his regulated brokerage and get the best of profits making

  37. Martini Waffle

    December 2, 2020 at 11:50 am

    Ever since I started ever since I started trading I have been making losses .ther came a day where I felt like I was on top of the world it’s such an amazing feeling,I had first become successful in my trades with Mr Peter schiff of course I am meant to testify cause he has real good works

    • Martini Waffle

      December 2, 2020 at 11:50 am

      ‪+44 7393 152637‬

  38. Lakshmi Narayan

    December 2, 2020 at 11:53 am

    Straining through expertised trades from India 🇮🇳 has really been of much use to me cause I got recommendations from a sibling who invested and got profited with Mr Peter schiff referred me to his regulated brokerage in which I start of 51000inr and I was scared 😱 cause I initially I’ll get scammed but to my greatest surprise I got bountiful profits in due time of trades I really appreciate starting off trades with you sir more trades to come .

    • Lakshmi Narayan

      December 2, 2020 at 11:53 am

      ‪+44 7393 152637‬

  39. Raheem Upendra

    December 2, 2020 at 11:55 am

    Because it’s speculation guess although intelligent ones done by professional for you to make this kind of profit you need. Certain thing on how the stock pushes tomorrow nobody has the power for beginners my advice is to get an experience trader like Mr Peter m schiff and get real expertised trades and huge earns in 24 hours .

    • Raheem Upendra

      December 2, 2020 at 11:56 am

      ‪+44 7393 152637‬

  40. Linexxlol

    December 2, 2020 at 12:11 pm

    Is she just reading off a script? she is soooo monotone jesus.

    • MAYBE HUMAN

      December 2, 2020 at 5:40 pm

      traumatized person..

  41. الجراح - AL-jarah

    December 2, 2020 at 12:12 pm

    ﴿وَما خَلَقتُ الجِنَّ وَالإِنسَ إِلّا لِيَعبُدونِ﴾ [الذاريات: ٥٦]
    And I did not create the jinn and mankind except to worship Me.
    – Saheeh International

    ﴿ما أُريدُ مِنهُم مِن رِزقٍ وَما أُريدُ أَن يُطعِمونِ﴾ [الذاريات: ٥٧]
    I do not want from them any provision, nor do I want them to feed Me.
    – Saheeh International

    ﴿إِنَّ اللَّهَ هُوَ الرَّزّاقُ ذُو القُوَّةِ المَتينُ﴾ [الذاريات: ٥٨]
    Indeed, it is Allāh who is the [continual] Provider, the firm possessor of strength.
    – Saheeh International

    ﴿فَإِنَّ لِلَّذينَ ظَلَموا ذَنوبًا مِثلَ ذَنوبِ أَصحابِهِم فَلا يَستَعجِلونِ﴾ [الذاريات: ٥٩]
    And indeed, for those who have wronged is a portion [of punishment] like the portion of their companions [i.e., predecessors], so let them not impatiently urge Me.
    – Saheeh International

    ﴿فَوَيلٌ لِلَّذينَ كَفَروا مِن يَومِهِمُ الَّذي يوعَدونَ﴾ [الذاريات: ٦٠]
    And woe to those who have disbelieved from their Day which they are promised.
    – Saheeh International

  42. Evolved Copper

    December 2, 2020 at 2:04 pm

    I just want to get a job.

  43. christianv80

    December 2, 2020 at 2:25 pm

    Just don’t make that crap mandatory otherwise thank you for being brave in volunteering .

  44. Alexander Vok

    December 2, 2020 at 5:29 pm

    I think that in the first place less educated/less performing humans should volonteer to take part in the vaccine trials as objects. Viruses don’t care as biologically those people are still humans but it might be difficult for them to contribute to humanity in some other way. That lady seems to have decided that the best she can do is to take part in the trials (she might have lost her job anyway). Thanks for contributing in any case!

  45. Tesse Veelo

    December 2, 2020 at 6:43 pm

    I salute you! Not just for your courage, but also for your thoroughly well thought through video! Thank you!!!
    With Love from Amsterdam.

  46. Paxton Wadams

    December 2, 2020 at 6:49 pm

    hi

  47. mihdd

    December 2, 2020 at 8:00 pm

    This vac makes you a robot as you can see.

  48. jp t

    December 2, 2020 at 8:46 pm

    At your age, you should have better dream than wasting your soul for the multimillionnaires. Its sad😥

  49. Linguinext

    December 3, 2020 at 12:56 am

    thank you for volunteering

  50. Dennis Wilson

    December 3, 2020 at 3:53 am

    You won’t find 8 million morons to take that poison so gl with the 8 billion. I feel bad for all the guinea pigs that do though. Your deaths will be in vain.

  51. Greg Nickolson

    December 3, 2020 at 4:40 am

    Got about halfway through.. then felt I was being sold on a jab in the arm

  52. Expertreporter Smith

    December 3, 2020 at 2:02 pm

    You are awesome. ty.

  53. Psalm 121

    December 3, 2020 at 4:01 pm

    This is the way I see it. Bill Gates wants to give you a vaccine, but doesn’t want to take responsibility when injuries and/or death occurs. Something else to consider is BG doesn’t have his children get vaccined. Doctors and the elite will be given a placebo making out like they are getting the real thing.

  54. Julieta Osorio

    December 4, 2020 at 4:50 pm

    No entendí una wea, pero sí…

  55. Truthwillsetyoufree777

    December 5, 2020 at 5:37 pm

    Mindless zombies

  56. WhiteSpatula

    December 6, 2020 at 10:14 am

    Thank you..Thank you. Thank you. And to anyone who doesn’t want to mask up in public, please just consider thinking of it this way: Despite the muffling of my voice, the occasional fogging of my glasses when I exhale, and even the possibility I may already have contracted and conquered this virus myself, wearing a facemask in public during this crisis is simply my way of saying to everyone else out there, “Howdy, neighbor. Boy oh boy, I sure wouldn’t kill your grandma if I had the chance. No sir-ee! Well, safe travels and best regards!” Cheers! -Phill, Las Vegas

  57. TyGurr Artistry

    December 7, 2020 at 12:03 am

    Bravo for having the courage to step forward in helping researchers find their solution!

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