Lori Keith, Parnassus Investments portfolio manager and senior analyst, says megacaps are not the only way to play the AI boom. She shares where she sees opportunities in mid-caps — from the companies powering the buildout to those using AI to boost productivity. She joins Ed Ludlow on “Bloomberg Tech.”
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Genome researcher Michael Snyder believes health wearables, such as smart watches and glucose monitors, can transform medicine, shifting from reactive to predictive. (In fact, he’s such a big fan of these devices that he wears eight of them every single day.) From spotting an illness days before symptoms appear to helping prevent the onset of diabetes, learn why the future of health care may be on your wrist.

Immigrant founders have built some of the world’s most valuable companies, but many still face barriers that make it harder to get a startup off the ground. Visa restrictions, limited access to friends-and-family capital, shallow networks, and a venture industry built around pattern matching can keep promising founders from getting funded before they have a chance to prove themselves.

In this episode of Build Mode () , host Isabelle Johannesen sits down with Manan Mehta, co-founder and managing partner of Unshackled Ventures, () to talk about why he believes immigrant founders represent one of venture capital’s biggest overlooked opportunities. Manan breaks down how Unshackled built an investment model designed to help founders navigate immigration barriers, why traditional VC pattern matching causes investors to miss potential outliers, and how his team evaluates founders at day zero—often before they have a product, customers, or traction. He also explains why the structural gaps that make some founders harder to fund may be exactly where investors should be looking for outsized returns.

They get into:

•

The four structural barriers immigrant founders face when starting companies in the U.S.

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How Unshackled Ventures helps founders navigate visas while building their startups

•

Why VC’s reliance on pattern matching can cause investors to miss outlier founders

•

How Manan evaluates founders before they have a product, customers, or traction

•

The IQ, AQ, EQ, and SQ framework Unshackled uses to evaluate founder potential

•

Why resilience, lived experience, and a founder’s relationship to the problem can matter more than a polished pitch

•

Why structural gaps can create some of the biggest opportunities for investors

•

How founders without traditional networks can find alternative paths to early capital

•

Why founders should understand their personal “why” instead of trying to fit the traditional VC mold

Subscribe to Build Mode on Apple Podcasts () , Spotify () , or wherever you like to listen () . And watch the full videos on YouTube () . New episodes of Build Mode () drop every Thursday.

Chapters:

00:00 – Why VCs Miss Outlier Founders

01:45 – Why Manan Mehta Founded Unshackled Ventures

04:15 – The Problem With VC Pattern Matching

06:15 – The Friends-and-Family Gap for Immigrant Founders

08:18 – How Unshackled Helps Founders Navigate Visas

10:40 – Building a Startup in Today’s Immigration Environment

12:19 – Solving One of Unshackled’s Hardest Immigration Cases

14:39 – What the U.S. Stands to Lose16:59 – Raising Unshackled’s First Venture Funds

19:40 – Can You Start a Company on an H-1B Visa?

22:13 – How to Evaluate a Founder at Day Zero

28:30 – Measuring IQ, AQ, EQ, and SQ

30:26 – How Fear Drives VC Pattern Matching

33:01 – Why Structural Gaps Create Outlier Opportunities

35:14 – Finding Startup Capital Outside Traditional VC

38:09 – Why Founders Need to Understand Their “Why”

Hosted by Isabelle Johannesen. Produced and edited by Maggie Nye. Audience development led by Morgan Little. Special thanks to the Foundry and Cheddar video teams.